CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1035-0005-5mg | $120 | ||
| VD-OEIA-1035-0025-25mg | $420 |
SNS 032
$120.00 – $420.00
Product Specification
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Appearance:
N/A
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CAS Number:
345627-80-7
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Cat.number:
VD-OEIA-1035
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Formula:
C17H24N4O2S2
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MW:
380.53
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Purity:
>=99%
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Solubility:
DMSO
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Storage:
N/A
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Synonyms:
BMS 387032; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio) thiazol-2-yl)piperidine-4-carboxamide
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Size:
25mg, 5mg
Description
Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9 (IC50 values to be 38, 4 and 62 nM for cdk2, cdk7 and cdk9 respectively and no activity against 190 additional kinases); SNS 032 induces cell cycle arrest and apoptosis in tumor cell lines.
1. DS Williamson et al. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg. Med. Chem. Lett. 2005, 15(4), 863-867.
2. R Chen et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood, 2009, 113(19), 4637-4645.
3. WG Tong et al. Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma. J. Clin. Oncol. 2010, 28(18), 3015-3022.
4. MA Dickson and GK Schwartz. Development of cell-cycle inhibitors for cancer therapy. Curr. Oncol. 2009, 16(2), 36-43.
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