CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-NP-0143-0010-10mg | $95 | ||
| VD-NP-0143-0100-100mg | $730 |
STAT5 Inhibitor (CAS 285986-31-4)
$95.00 – $730.00
Product Specification
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Appearance:
White solid.
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CAS Number:
285986-31-4
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Cat.number:
VD-NP-0143
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Formula:
C16H11N3O3
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MW:
293.3
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Purity:
≥97%
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Solubility:
DMSO (10 mg/ml).
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
(E)-N’-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
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Size:
100mg, 10mg
Description
STAT5 Inhibitor (CAS 285986-31-4) is a cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50=47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50>500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells. Solutions are stable for up to 3 months at -20°C.
1. Muller, J., et al. 2008. ChemBioChem 9, 723.
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