CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0104-0010-10mg | $130 | ||
| VD-AM-0104-0050-50mg | $400 |
HA 1100 hydrochloride (CAS 155558-32-0)
$130.00 – $400.00
Product Specification
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Appearance:
Not available
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CAS Number:
155558-32-0
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Cat.number:
VD-AM-0104
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Formula:
C14H17N3O3S.HCl
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MW:
34383
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Purity:
>=98%
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Solubility:
Water
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Storage:
-20°C
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Synonyms:
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl] hexahydro-1H-1,4-diazepine hydrochloride; 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one
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Size:
10mg, 50mg
Description
HA 1100 hydrochloride (CAS 155558-32-0) or Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. Fasudil (1-10 μM) and hydroxyfasudil (0.3-10 μM) significantly prevented endothelin-induced cardiomyocyte hypertrophy. Hydroxyfasudil significantly attenuated serotonin (IC)-induced vasoconstriction of SA. Coronary I/R significantly impaired coronary vasodilation to acetylcholine after I/R and L-NMMA further reduced the vasodilation, whereas hydroxyfasudil completely preserved the responses. Treatment with hydroxyfasudil significantly improved bladder intercontraction intervals. Rats treated with hydroxyfasudil also showed a significant reduction of histopathological features associated with cystitis. Treatment with hydroxyfasudil significantly improved the decreased penile cGMP concentrations, the increased Rho kinase activities, the increased norepinephrine-induced contractions, and the decreased acetylcholine-induced relaxation in a dose-dependent manner.
Not available.
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