CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10015-0010-10mg | $80 | ||
| VD-OEIA-10015-0050-50mg | $300 |
Stem-Cell Factor/c-Kit Inhibitor, ISCK03
$80.00 – $300.00
Product Specification
-
Appearance:
Dark yellow solid
-
CAS Number:
945526-43-2
-
Cat.number:
VD-OEIA-10015
-
Formula:
C19H21N3O2S
-
MW:
355.5
-
Purity:
≥97%
-
Solubility:
DMSO, EtOH.
-
Storage:
+2°C to +8°C. Protect from light.
-
Synonyms:
SCF/c-Kit Signaling Inhibitor, ISCK03
-
Size:
10mg, 50mg
Description
In 501mel melanoma cells, this cell-permeable, phenyl-imidazolosulfonamide compound has demonstrated inhibitory c-kit activity and blocks SCF-induced c-kit and Erk phosphorylation without any effect on HGF-induced Erk phosphorylation. Oral administration of ISCK03 is also shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Additionally, topical application has been demonstrated to diminish UV-induced pigmentation and epidermal melanin level, in Brownish guinea pigs in vivo.
1. Na, Y.J., et al. 2007. Biochem. Pharmacol. 74: 780-786.
Reviews
There are no reviews yet.