CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10016-0025-25mg | $120 | ||
| VD-OEIA-10016-0100-100mg | $350 |
Ubiquitin E1 Inhibitor
$120.00 – $350.00
Product Specification
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Appearance:
Dark purple solid
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CAS Number:
418805-02-4
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Cat.number:
VD-OEIA-10016
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Formula:
C17H13N3O7 • 3H2O
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MW:
425.4
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Purity:
≥90% (sum of two isomers)
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Solubility:
DMSO
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Storage:
-20°C. Protect from light.
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Synonyms:
Ubiquitin-Activating Enzyme E1 Inhibitor; PYR-41
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Size:
100mg, 25mg
Description
This product is a cell-permeable pyrazone compound that is reported to irreversibly inhibit ubiquitin-activating enzyme E1 activity, in addition to exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Also reported to block ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
1.Yang, Y., et al. 2007. Cancer Res. 67: 9472-9481.
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