CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AIH-0275-0010-10mg | $80 | ||
| VD-AIH-0275-0050-50mg | $380 |
Apoptosis Inhibitor II, NS3694, (CAS 426834-38-0)
$80.00 – $380.00
Product Specification
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Appearance:
White Solid
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CAS Number:
426834-38-0
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Cat.number:
VD-AIH-0275
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Formula:
C15H10ClF3N2O3
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MW:
358.7
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
+2°C to +8°C
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Synonyms:
4-chloro-2-(3-(3-(trifluoromethyl)phenyl)ureido)benzoic acid
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Size:
10mg, 50mg
Description
Apoptosis Inhibitor II, NS3694, (CAS 426834-38-0) is a cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054, NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
1.Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
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