CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0034-0005-5mg | $40 | ||
| VD-AI-0034-0050-50mg | $350 |
MG-132 (CAS 133407-82-6)
$40.00 – $350.00
Product Specification
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Appearance:
Crystalline solid
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CAS Number:
133407-82-6
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Cat.number:
VD-AI-0034
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Formula:
C26H41N3O5
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MW:
475.62
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Purity:
≥98%
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Solubility:
DMSO, EtOH.
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Storage:
-20°C
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Synonyms:
Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO
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Size:
50mg, 5mg
Description
MG-132 (CAS 133407-82-6) is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-B activation (IC50 = 3 M). Prevents -secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 in DMSO is also available.
1. Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
2. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
3. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
4 .Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
5. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
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