CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-ESA-0016-0010-10mg | $110 | ||
| VD-ESA-0016-0050-50mg | $420 |
BAY 41-2272 (CAS 256376-24-6)
$110.00 – $420.00
Product Specification
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Appearance:
White Solid
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CAS Number:
256376-24-6
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Cat.number:
VD-ESA-0016
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Formula:
C20H17FN6
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MW:
360.41
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Purity:
>=98%
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Solubility:
100 mM in DMSO
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Storage:
+4˚C
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Synonyms:
BAY 41-2272, Riociguat
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Size:
10mg, 50mg
Description
BAY 41-2272 (CAS 256376-24-6) is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
1. Mittendorf et al (2009) ChemMedChem 4 853.
2. Stasch et al (2010) Nature 410 212.
3. Joshi et al (2011) J.Pharmacol.Exp.Ther. 339 394.
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