CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0064-0010-10mg | $90 | ||
| VD-IS-0064-0050-50mg | $425 |
BIO (CAS 667463-62-9)
$90.00 – $425.00
Product Specification
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Appearance:
Dark red solid
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CAS Number:
667463-62-9
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Cat.number:
VD-IS-0064
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Formula:
C16H10BrN3O6
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MW:
356.17
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Purity:
≥97% by HPLC
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Solubility:
100 mM in DMSO, to 10 mM in EtOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
GSK-3 Inhibitor IX; (2’Z,3’E)-6-Bromoindirubin-3′-oxime
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Size:
10mg, 50mg
Description
BIO (CAS 667463-62-9) is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro.
1. Meijer et al (2003) Chem.Biol. 10 1255.
2. Polychronopoulos et al (2004) J.Med.Chem. 47 935.
3. Tseng et al (2006) Chem.Biol. 13 957.
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