CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-NP-0064-0001-1mg | $80 | ||
| VD-NP-0064-0005-5mg | $312 |
Biotin-FA-FMK
$80.00 – $312.00
Product Specification
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Appearance:
Off-white solid.
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CAS Number:
Not available.
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Cat.number:
VD-NP-0064
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Formula:
C27H36FN5O7S
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MW:
593.66
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Purity:
>=95%
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Solubility:
DMSO
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Storage:
Stock solutions in DMF or DMSO may be stored at -20 °C for up to one year.
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Synonyms:
Biotin-Phe-Ala-Fluoromethylketone; Biotin-Phe-Ala-FMK
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Size:
1mg, 5mg
Description
Biotin-Phe-Ala-Fluoromethyl Ketone is a cell permeable, biotinylated analog of the cathespin inhibitor Z-Phe-Ala-Fluoromethyl Ketone (Z-FA-FMK).Z-FA-FMK inhibits the cysteine proteases, Cathepsins B and L,1 but is not known to inhibit caspase enzymes.2,3 The concentration range for inhibition is 0.5 to 10 mM. Another similar analog, Biotin-Phe-Aladiazomethanealso inhibits Cathespin B. 4
1.Nisbet, A.J., and Billingsley, P.F., A comparative survey of the hydrolytic enzymes of ectoparasitic and free-living mites. Int J Parasitol., 30,19-27 (2000).
2.Gregoli, P.A., and Bondurant, M.C., Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J. Cell Physiol., 178, 133-43 (1999).
3.McColl, K.S. et al., Apoptosis induction by the glucocorticoid hormone dexamethasone and the calcium-ATPase inhibitor thapsigargin involves Bc1-2 regulated caspase activation. Mol. Cell Endocrinol., 139, 229-38 (1999).
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