CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0269-0100-100mg | $80 | ||
| VD-AI-0269-0300-300mg | $200 |
TPEN (CAS 16858-02-9)
$80.00 – $200.00
Product Specification
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Appearance:
Solid.
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CAS Number:
16858-02-9
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Cat.number:
VD-AI-0269
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Formula:
C26H28N6
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MW:
424.6
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Purity:
>=97%
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Solubility:
Dimethyl formamide, DMSO, 100% Ethanol or Methanol.
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Storage:
+4°C to +8°C. Protect from light.
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Synonyms:
N,N,N’,N’-Tetrakis-(2-pyridylmethyl)ethylenediamine
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Size:
100mg, 300mg
Description
TPEN (CAS 16858-02-9) is a cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 or QUIN 2/AM to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Complex with Fe2+ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in T cells.
1. P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985).
2. T. Nagano et al.; J. Biol. Chem. 264, 9243 (1989).
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