CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0114-0005-5mg | $80 | ||
| VD-CCR-0114-0050-50mg | $425 |
Cdk1 Inhibitor (CAS 220749-41-7)
$80.00 – $425.00
Product Specification
-
Appearance:
Orange solid
-
CAS Number:
220749-41-7
-
Cat.number:
VD-CCR-0114
-
Formula:
C17H11ClN2O
-
MW:
294.7
-
Purity:
≥95% by HPLC
-
Solubility:
DMSO
-
Storage:
+2°C to +8°C. Protect from light.
-
Synonyms:
3-(2-Chloro-3-indolylmethylene)- 1,3-dihydroindol-2-one
-
Size:
50mg, 5mg
Description
Cdk1 Inhibitor (CAS 220749-41-7) is an indolylmethylene-2-indolinone derivative that exhibits potent antiproliferativeproperties (IC50 = 2 μM HeLa cells). Acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 μM). Also inhibits Cdk5 with a IC50 = 25 μM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 μM concentrations.
1. Andreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
2. Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
Reviews
There are no reviews yet.