CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0214-0010-10mg | $80 | ||
| VD-OEIA-0214-0050-50mg | $340 |
Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1)
$80.00 – $340.00
Product Specification
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Appearance:
White solid.
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CAS Number:
511296-88-1
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Cat.number:
VD-OEIA-0214
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Formula:
C16H16N2S.HBr
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MW:
349.29
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Purity:
>98%
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Solubility:
100 mM in DMSO and to 10 mM in ethanol.
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Storage:
RT
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Synonyms:
Pifithrin-beta
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Size:
10mg, 50mg
Description
Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1) is a cyclic analog of pifithrin-α (VD-OEIA-0214), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
1. Barchechath et al (2005) J.Med.Chem. 48 6409.
2. Pietrancosta et al (2005) Bioorg.Med.Chem.Lett. 15 1561.
3. Zuco and Zunino (2008) Neoplasia 10 587.
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