CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-Ant-0343-0025-25g | $180 | ||
| VD-Ant-0343-0100-100g | $520 |
DEPBT
$180.00 – $520.00
Product Specification
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Appearance:
White to yellow powder
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CAS Number:
165534-43-0
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Cat.number:
VD-Ant-0343
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Formula:
C11H14N3O5P
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MW:
299.22
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Purity:
≥95%
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Storage:
Longterm storage temperature: -20 ± 5 °C
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Synonyms:
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; Chemical name: diethyl 4-oxobenzo[d] [1,2,3]triazin-3(4H)-yl phosphate
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Size:
100g, 25g
Description
This new crystalline phosphate reagent mediates amide bond formation with a remarkable resistance to racemization. Thus, DEPBT is an excellent activation reagent for coupling the racemization-prone Fmoc-His(Trt)-OH. The use of DEPBT permitted the total synthesis of the antiviral peptide antibiotic feglymycin, which contains a high proportion of ring-substituted phenylglycines.
C.-X.Fan et al., Synth. Commun., 26, 1455 (1996). H.Li et al., Org. Lett., 1, 91 (1999). M.Mergler et al., Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 7th International Symposium, Southampton, p. 235, R.Epton, ed., Mayflower Worldwide, (2002). F.Dettmer et al., Angew. Chem. Int. Ed. Engl., 48, 1856 (2009).
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