CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0109-0010-10mg | $100 | ||
| VD-AM-0109-0050-50mg | $460 |
DAPT (CAS 208255-80-5)
$100.00 – $460.00
Product Specification
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Appearance:
White solid.
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CAS Number:
208255-80-5
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Cat.number:
VD-AM-0109
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Formula:
C23H26F2N2O4
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MW:
432.46
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Purity:
≥95%
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Solubility:
100 mM in DMSO
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Storage:
-20°C.Protect from light.
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Synonyms:
γ-Secretase inhibitor
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Size:
10mg, 50mg
Description
DAPT (CAS 208255-80-5) is an inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not effect APPα and APPβ levels. Blocks notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC)
1.Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
2.Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
3.Oddo, S., et al. 2004. Neuron 43, 321.
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