CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0131-0005-5mg | $100 | ||
| VD-IS-0131-0025-25mg | $350 |
JAK2 Inhibitor IV (CAS 1110502-30-1)
$100.00 – $350.00
Product Specification
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Appearance:
Pale yellow solid
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CAS Number:
1110502-30-1
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Cat.number:
VD-IS-0131
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Formula:
C17H20N4O2S
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MW:
344.4
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Purity:
≥97% by HPLC
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Solubility:
DMSO or EtOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
4-(3-amino-1H-indazol-4-yl)-N- (tert-butyl)benzenesulfonamide
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Size:
25mg, 5mg
Description
JAK2 Inhibitor IV (CAS 1110502-30-1) is an aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
1.Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.
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