CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0073-0001-1mg | $80 | ||
| VD-IS-0073-0005-5mg | $350 |
K-252c (CAS 85753-43-1)
$80.00 – $350.00
Product Specification
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Appearance:
Off-white solid.
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CAS Number:
85753-43-1
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Cat.number:
VD-IS-0073
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Formula:
C20H13N3O
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MW:
311.34
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Purity:
>=99%
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Solubility:
25 mM in DMSO.
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Storage:
-20°C.Protect from light.
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Synonyms:
Staurosporinone
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Size:
1mg, 5mg
Description
K-252c (CAS 85753-43-1) is an inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13-0.32 μM). Shows no activity against herpes simplex virus (HSV).
1. Fabre et al (1993) Bioorg.Med.Chem. 1 193.
2. Zimmermann et al (2000) Antiviral Res.48 49.
3. McGovern and Shoichet (2003) J.Med.Chem. 46 1478.
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