CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| Vd-ESA-0022-0010-10mg | $80 | ||
| VD-ESA-0022-0050-50mg | $320 |
PAC 1 (CAS 138605-00-2)
$80.00 – $320.00
Product Specification
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Appearance:
White Solid
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CAS Number:
315183-21-2
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Cat.number:
VD-ESA-0022
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Formula:
C23H28N4O2
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MW:
392.5
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Purity:
>98%
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Solubility:
75 mM in 1eq. HCl and to 100 mM in DMSO.
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Storage:
+4˚C
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Synonyms:
PAC-1,
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Size:
10mg, 50mg
Description
PAC 1 (CAS 315183-21-2) is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 – 1.41 and 5.02 – 9.98 μM respectively).
1. Putt et al (2006) Nat.Chem.Biol. 2 543.
2. Peterson et al (2009) J.Med.Chem. 52 5721.
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