CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1044-0010-10mg | $80 | ||
| VD-OEIA-1044-0050-50mg | $300 |
PF 915275
$80.00 – $300.00
Product Specification
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Appearance:
White solid.
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CAS Number:
857290-04-1
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Cat.number:
VD-OEIA-1044
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Formula:
C18H14N4O2S
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MW:
350.39
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Purity:
>=98%
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Solubility:
100 mM in DMSO.
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Storage:
Room temperature.
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Synonyms:
N-(6-Amino-2-pyridinyl)-4′-cyano-[1,1′-biphenyl]-4-sulfonamide
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Size:
10mg, 50mg
Description
Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki=2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50=15 nM) and has antidiabetic activity in vivo. Orally active.
1.Bhat et al (2008).J.Pharmacol.Exp.Ther. 324 299.
2.Fotsch and Wang (2008).J.Med.Chem. 51 4851.
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