CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0217-0025-25mg | $200 | ||
| VD-OEIA-0217-0100-100mg | $600 |
PIM-Kinase Inhibitor IX, SGI-1776 (CAS 1025065-69-3)
$200.00 – $600.00
Product Specification
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Appearance:
A crystalline solid.
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CAS Number:
1025065-69-3
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Cat.number:
VD-OEIA-0217
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Formula:
C20H22F3N5O
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MW:
601.6
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Purity:
>=99%.
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Solubility:
DMSO or H₂O.
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Storage:
+2°C to +8°C.
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Synonyms:
SGI 1776
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Size:
100mg, 25mg
Description
PIM-Kinase Inhibitor IX, SGI-1776 (CAS 1025065-69-3) is a cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases.
1.Chen, L.S., et al. 2011. Blood 118, 693.
2.Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
3.Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther. 8, 2882.
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