CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10004-0005-5mg | $100 | ||
| VD-OEIA-10004-0025-25mg | $350 |
sFRP-1 Inhibitor
$100.00 – $350.00
Product Specification
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Appearance:
Clear oil
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CAS Number:
915754-88-0
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Cat.number:
VD-OEIA-10004
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Formula:
C19H26N2O4S2
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MW:
410.6
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Purity:
≥95%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Secreted Frizzled Related Protein-1 Inhibitor
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Size:
25mg, 5mg
Description
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50=1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
1.Gopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.
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