CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0052-0001-5mg | $150 | ||
| VD-AM-0052-0005-50mg | $1200 |
SU 5402 (CAS 215543-92-3)
$150.00 – $1,200.00
Product Specification
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Appearance:
Dark orange solid
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CAS Number:
215543-92-3
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Cat.number:
VD-AM-0052
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Formula:
C17H16N2O3
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MW:
296.32
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Purity:
≥97%
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Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
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Storage:
-20°C
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Synonyms:
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene) methyl]-4-meth yl-1H-pyrrole-3-propanoic acid
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Size:
50mg, 5mg
Description
SU 5402 (CAS 215543-92-3) is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. SU 5402 is a fibroblast growth factor receptor (FGFR)-specific tyrosine kinase inhibitor. Multiple myeloma studies suggest that SU 5402 inhibits FGFR3 phosphorylation in vitro. Research shows that inhibition of FGFR results in the blocking of nodal vesicular parcels (NVPs) secretion and an increase of Ca2+. Additionally, SU 5402 has been observed to inhibit IL-1β-induced MAPK activity.
1. Sun et al (1999) J.Med.Chem. 42 5120.
2. Paterson et al (2004) Br.J.Haematol. 124 595.
3. Tanaka et al (2005) Nature 435 172.
4. Paterson, J.L., et al. 2004. Br. J. Haematol. 124: 595-603.
5. Tanaka, Y., et al. 2005. Nature. 435: 172-177.
6. Petersen, L.G., et al. 2006. Diabetologia. 49: 1864-187
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