CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0053-0010-10mg | $100 | ||
| VD-AM-0053-0050-50mg | $400 |
SU 6668 (CAS 252916-29-3)
$100.00 – $400.00
Product Specification
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Appearance:
Orange-red solid.
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CAS Number:
252916-29-3
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Cat.number:
VD-AM-0053
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Formula:
C18H18N2O8
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MW:
310.35
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Purity:
>=99%
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Solubility:
100 mM in 1eq. NaOH and to 100 mM in DMSO
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Storage:
RT. Keep cool and dry.
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Synonyms:
Orantinib
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Size:
10mg, 50mg
Description
SU 6668 (CAS 252916-29-3) is a ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and >100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces >75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapototic activity and is orally active.
1.Sun et al (1999).J.Med.Chem. 42 5120.
2.Laird et al (2000).Cancer Res. 60 4152.
3.Yamamoto et al (2008).Cancer Res. 68 9754.
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