CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0011-0001-1mg | $200 | ||
| VD-OEIA-0011-0005-5mg | $800 |
TAPI-2 (CAS 187034-31-7)
$200.00 – $800.00
Product Specification
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Appearance:
Lyophilized solid.
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CAS Number:
187034-31-7
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Cat.number:
VD-OEIA-0011
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Formula:
C19H37N5O5
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MW:
415.5
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Purity:
>=97% by HPLC
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Solubility:
EtOH or H2O
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Storage:
-20°C. Protect from light. Hygroscopic.
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Synonyms:
TNF-α Protease Inhibitor-2
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Size:
1mg, 5mg
Description
TAPI-2 (CAS 187034-31-7) is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 μM).
1.Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
2.Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
3.Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
4.Parvathy, S., et al. 1997. Biochem. J. 327, 37.
5.Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
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