CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0088-0100-100mg | $25 | ||
| VD-IS-0088-0500-500mg | $100 |
Valproic acid, sodium salt (CAS 1069-66-5)
$25.00 – $100.00
Product Specification
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Appearance:
White crystalline solid.
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CAS Number:
1069-66-5
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Cat.number:
VD-IS-0088
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Formula:
C8H15NaO2
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MW:
166.19
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Purity:
N/A
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Solubility:
100 mM in water and to 50 mM in DMSO
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Storage:
RT
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Synonyms:
SodiumValproate; Sodium 2-propylpentanoate
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Size:
100mg, 500mg
Description
Valproic acid, sodium salt (CAS 1069-66-5) is a histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer’s disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons.
1. Phiel et al (2001) J.Biol.Chem. 276 36734.
2. Kostrouchova et al (2007) Folia Biologica 53 37.
3. Kim et al (2007) J.Pharmacol.Exp.Ther. 321 892.
4. Qing et al (2008) J.Exp.Med. 205 2781.
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