Product Variations
Product # | Price | Quantity | |
---|---|---|---|
VD-AM-0123-0010-10mg | $70 | ||
VD-AM-0123-0050-50mg | $325 |
$70.00 – $325.00
Red solid.
163655-37-6
VD-AM-0123
C21H18N2O
314.1
≥95% by HPLC
DMSO
+2°C to +8°C. Protect from light.
MAZ51; Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor
10mg, 50mg
Product # | Price | Quantity | |
---|---|---|---|
VD-AM-0123-0010-10mg | $70 | ||
VD-AM-0123-0050-50mg | $325 |
VEGFR3 Kinase Inhibitor (CAS 163655-37-6) is a cell-permeable 3-substituted indolin-2-one compound that acts as an ATPcompetitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 μM), it specifically blocks VEGF-C- and VEGF-D- induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis.
1. Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530.
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