CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CRP-0165-0005-5mg | $70 | ||
| VD-CRP-0165-0050-50mg | $650 |
Z-DEVD-AFC (Fluorogenic substrate for Caspase-3)
$70.00 – $650.00
Product Specification
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Appearance:
White or off-white solid
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Cat.number:
VD-CRP-0165
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Formula:
C36H38F3N5O14
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MW:
821.7
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
-20°C : Shipped on Blue ice
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Synonyms:
Z-Asp-Glu-Val-Asp-AFC; Z-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin
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Size:
50mg, 5mg
Description
A fluorogenic substrate for Caspase-3 (CPP32, YAMA). Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Kluck, R.M., et al. 1997. Science 275, 1132.
Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
Nicholson, D.W., et al. 1995. Nature 376, 37.
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