CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0272-0050-50mg | $300 | ||
| VD-AI-0272-0010-10mg | $70 |
Mitomycin C
$70.00 – $300.00
Product Specification
-
Appearance:
Blue-violet solid.
-
CAS Number:
50-07-7
-
Cat.number:
VD-AI-0272
-
Formula:
C15H18N4O5
-
MW:
334.33
-
Purity:
>=95%.
-
Solubility:
5 mM in H2O and to 100 mM in DMSO.
-
Storage:
+2°C to +8°C. Protect from light.
-
Synonyms:
Ametycine; MMC
-
Size:
10mg, 50mg
Description
Antibiotic and antitumor agent. Covalently binds DNA forming intra-and interstrand crosslinks. Inhibits DNA synthesis. Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent making it useful as an antibiotic antitumor product. When crosslinking Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation caspases 3,8, and 9 activating both the intrinsic and extrinsic pathway for apoptosis.
1.Kruyt, F.A., et al. 1996. Blood 89, 938.
2.Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
3.Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
4.Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
Reviews
There are no reviews yet.