CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0060-0010-10mg | $120 | ||
| VD-IS-0060-0050-50mg | $550 |
1-Naphthyl PP1 (CAS 221243-82-9)
$120.00 – $550.00
Product Specification
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Appearance:
White cyrstalline solid
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CAS Number:
221243-82-9
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Cat.number:
VD-IS-0060
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Formula:
C19H19N5
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MW:
317.39
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Purity:
≥99%
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Solubility:
50 mM in DMSO, MeOH
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Storage:
+4°C.
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Synonyms:
1-NA-PP 1
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Size:
10mg, 50mg
Description
1-Naphthyl PP1 (CAS 221243-82-9) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).1. Bishop et al (1999) J.Am.Chem.Soc. 121 627.
2. Bishop et al (2000) Nature 407 395.
2. Bishop et al (2000) Nature 407 395.
1. Bishop et al (1999) J.Am.Chem.Soc. 121 627.
2. Bishop et al (2000) Nature 407 395.
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