CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-NP-0054-0005-5mg | $106 | ||
| VD-NP-0054-0050-50mg | $950 |
Ac-IETD-AFC (CAS 211990-57-7)
$106.00 – $950.00
Product Specification
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Appearance:
Lyophilized solid.
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CAS Number:
211990-57-7
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Cat.number:
VD-NP-0054
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Formula:
C31H38F3N5O12
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MW:
729.65
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Purity:
≥97% (HPLC)
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Solubility:
Dimethylsulfoxide (DMSO) to 50 mg/ml.
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Storage:
−20°C; Shipped on dry ice
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Synonyms:
N-acetyl-Ile-Glu-Thr-Asp-AFC (7-amino-4-trifluoromethyl coumarin)
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Size:
50mg, 5mg
Description
Fluorogenic substrate for caspases-6 (Mch2), -8 (FLICE), -10 (Mch4) and related cysteine proteases. Similar to Ac-IETD-AMC but the AFC fluorophore has a greater Stokes’ shift upon cleavage. Reaction can be monitored quantitatively or visually by a blue to green shift in fluorescence upon cleavage.
1. N.A. Thornberry Methods Enzymol. 1994 244 615
2. R. Datta et al. J. Biol. Chem. 1997 272 1965
3. D.W. Nicholson et al. Nature (Lond.) 1995 376 37
4. Y.A. Lazebnik et al. Nature (Lond.) 1994 371 346
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