CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AIH-0124-0005-20mg | $60 | ||
| VD-AIH-0124-0050-200mg | $450 |
Necrostatin-1
$60.00 – $450.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
4311-88-0
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Cat.number:
VD-AIH-0124
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Formula:
C13H13N3OS
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MW:
259.3
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Purity:
≥99% by HPLC.
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Solubility:
DMSO or MeOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Nec-1; Necroptotic Inhibitor
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Size:
200mg, 20mg
Description
A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
1.Degterev, A., et al. 2008. Nat. Chem. Biol. in press.
2.Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
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