CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0277-0010-10mg | $115 | ||
| VD-AI-0277-0100-100mg | $1000 |
Apoptosis Activator 2
$115.00 – $1,000.00
Product Specification
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Appearance:
Orange solid
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CAS Number:
79183-19-0
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Cat.number:
VD-AI-0277
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Formula:
C15H9Cl2NO2
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MW:
306.1
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Purity:
>=95% by HPLC
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Solubility:
DMSO or MeOH
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Storage:
Protect from light. Packaged under inert gas.
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Synonyms:
1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
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Size:
100mg, 10mg
Description
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 – 9 μM for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
1.Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
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