CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0044-0010-10mg | $70 | ||
| VD-IS-0044-0050-50mg | $300 |
AG 18 (CAS 118409-57-7)
$70.00 – $300.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
118409-57-7
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Cat.number:
VD-IS-0044
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Formula:
C10H6N2O2
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MW:
186.17
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Purity:
≥98% by HPLC
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Solubility:
20 mM in EtOH, to 100 mM in DMSO or Acetic acid.
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Storage:
-20°C. Protect from light.
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Synonyms:
RG-50810; Tyrphostin A 23
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Size:
10mg, 50mg
Description
AG 18 (CAS 118409-57-7) is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
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3. Gazit et al (1989) J.Med.Chem. 32 2344.
4. Levitzki and Gazit (1995) Science 267 1782.
5. Soltoff (2004) J.Biol.Chem. 279 10910.
6. Jaleel, M., et al. 2004. Biochemistry 43, 8247.
7. Kapas, S., et al. 1995. Biochem. J. 305, 433.
8. Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
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