CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0043-0010-10mg | $60 | ||
| VD-IS-0043-0050-50mg | $250 |
AG 490 (CAS 133550-30-8)
$60.00 – $250.00
Product Specification
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Appearance:
Pale yellow solid.
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CAS Number:
133550-30-8
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Cat.number:
VD-IS-0043
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Formula:
C17H14N2O3
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MW:
294.31
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Purity:
>=98%
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Solubility:
20 mM in EthOH and to 100 mM in DMSO.
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Storage:
-20°C. Protect from light.
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Synonyms:
Tyrphostin
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Size:
10mg, 50mg
Description
AG 490 (CAS 133550-30-8) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.
1.Gazit et al (1991),J.Med.Chem. 34 1896.
2.Meydan et al (1996),Nature 379 645.
3.Wang et al (1999),J.Immunol. 162 3897.
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