CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0061-0005-5mg | $70 | ||
| VD-AM-0061-0050-50mg | $650 |
Akt Inhibitor XI (CAS 902779-59-3)
$70.00 – $650.00
Product Specification
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Appearance:
Green solid.
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CAS Number:
902779-59-3
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Cat.number:
VD-AM-0061
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Formula:
C11H9Cl2CuN3O2S
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MW:
381.7
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Purity:
≥98%
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Solubility:
H2O (5 mg/ml) or DMSO (2 mg/ml).
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Storage:
+2°C to +8°C.
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Synonyms:
FPA-124
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Size:
50mg, 5mg
Description
Akt Inhibitor XI (CAS 902779-59-3) is a cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.
1.Barve, V., et al. 2006. J. Med. Chem. 49, 3800.
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