CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0037-0001-1mg | $60 | ||
| VD-IS-0037-0005-5mg | $220 |
EGFR/ErbB-2 Inhibitor (CAS 179248-61-4)
$60.00 – $220.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
179248-61-4
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Cat.number:
VD-IS-0037
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Formula:
C23H21N3O3
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MW:
387.4
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Purity:
≥97% by HPLC
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Solubility:
DMSO or MeOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
4557W
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Size:
1mg, 5mg
Description
EGFR/ErbB-2 Inhibitor (CAS 179248-61-4) is a cell-permeable 4-anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM & 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 ~ 1.2-2.5 μM) of tumor cells overexpressing EGRF or c-erbB-2.
1. Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
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