CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0120-0005-5mg | $110 | ||
| VD-AM-0120-0010-10mg | $200 |
VEGFR Tyrosine Kinase Inhibitor II (CAS 269390-69-4)
$110.00 – $200.00
Product Specification
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Appearance:
White Solid
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CAS Number:
269390-69-4
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Cat.number:
VD-AM-0120
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Formula:
C19H16ClN3O
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MW:
337.8
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Purity:
≥98% by HPLC
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Solubility:
DMSO or MeOH
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Storage:
-20°C. Protect from light.
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Synonyms:
VEGF Receptor Tyrosine Kinase Inhibitor II
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Size:
10mg, 5mg
Description
VEGFR Tyrosine Kinase Inhibitor II (CAS 269390-69-4) is a pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. Shown to potently inhibit the kinase activities of KDR, Flt-1 and c-Kit (IC50=20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50=7 μM and 7.3 μM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50>10 μM).
1. Furet, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
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