CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0041-0050-50mg | $40 | ||
| VD-CCR-0041-0500-500mg | $350 |
H-Cys(Trt)-OH (CAS 2799-07-7)
$40.00 – $350.00
Product Specification
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Appearance:
White to off-white powder
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CAS Number:
2799-07-7
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Cat.number:
VD-CCR-0041
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Formula:
C22H21NO2S
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MW:
363.47
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Purity:
≥98 % by TLC
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Solubility:
50 mM in DMSO
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Storage:
-20°C
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Synonyms:
NSC 83265; S-Trityl-L-cysteine
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Size:
500mg, 50mg
Description
H-Cys(Trt)-OH (CAS 2799-07-7) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.
1. DeBonis et al (2004) Mol.Cancer Ther. 3 1079.
2. Brier et al (2004) Biochemistry 43 13072.
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