CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AM-0107-0001-1mg | $50 | ||
| VD-AM-0107-0010-10mg | $150 |
ZM 323881 hydrochloride (CAS 193000-39-4)
$50.00 – $150.00
Product Specification
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Appearance:
Light-brown solid.
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CAS Number:
193000-39-4
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Cat.number:
VD-AM-0107
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Formula:
C22H18FN3O2.HCl
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MW:
411.86
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Purity:
≥99%
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Solubility:
50 mM in DMSO
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Storage:
+4°C.
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Synonyms:
5‐{[7‐(benzyloxy)quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol hydrochloride
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Size:
10mg, 1mg
Description
ZM 323881 hydrochloride (CAS 324077-30-7) is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
1. Whittles et al (2002) Microcirculation 9 513.
2. Endo et al (2003) J.Recept.Signal Transduct.Res. 23 239.
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