CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-GFC-0032-0005-500μg | $148 | ||
| VD-GFC-0032-0001-1mg | $200 |
LFM-A12
$148.00 – $200.00
Product Specification
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Appearance:
White Solid
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Cat.number:
VD-GFC-0032
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Formula:
C12H9F3N2O3
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MW:
286.21
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from Light. Packaged under inert gas.
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Synonyms:
Chemical name: α-Cyano-β-hydroxy-β-methyl-N-[4-(trifluoromethoxy)phenyl]propenamide
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Size:
1mg, 500μg
Description
A potent and specific inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase in vitro (IC50 = 1.7 M). Kills over 99% of human breast cancer cells in vitro by triggering apoptosis. Even at high concentrations (175-350 M), LFM-A12 does not affect the enzymatic activity of other PTKs including BTK, HCK, IRK, JAK1, JAK3, and Syk.
Ghosh, S., et al. 1999. Clin. Cancer Res. 5, 4264. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Ghosh, S., et al. 1998. Clin. Cancer Res. 4, 2657.
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