CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0280-0010-10mg | $60 | ||
| VD-AI-0280-0100-100mg | $550 |
MIRA-1
$60.00 – $550.00
Product Specification
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Appearance:
White Solid
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CAS Number:
72835-26-8
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Cat.number:
VD-AI-0280
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Formula:
C8H9NO4
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MW:
183.16
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Purity:
≥95% by HPLC
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Solubility:
100 mM in DMSO and to 100 mM in Ethanol
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Storage:
+4°C.
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Synonyms:
1-[(1-Oxopropoxy)methyl]-1H-pyrrole 2,5-dione
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Size:
100mg, 10mg
Description
Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
1.Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168.
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