CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0077-0010-10mg | $90 | ||
| VD-CCR-0077-0050-50mg | $425 |
NU 2058 (CAS 161058-83-9)
$90.00 – $425.00
Product Specification
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Appearance:
White Solid
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CAS Number:
161058-83-9
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Cat.number:
VD-CCR-0077
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Formula:
C12H17N5O
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MW:
247.3
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Purity:
≥98% (HPLC)
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Solubility:
100 mM in DMSO, 10 mM in EtOH
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Storage:
+2°C to +8°C.
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Synonyms:
O6-Cyclohexylmethylguanine
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Size:
10mg, 50mg
Description
NU 2058 (CAS 161058-83-9) is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
1. Arris et al (2000) J.Med.Chem. 43 2797.
2. Knockaert et al (2002) TiPS 23 417.
3. Jensen et al (2005) Cancer Res. 65 7470.
4. Gibson, A. E., et al, J. Med. Chem. 45, 3381-3393 , (2002).
5. Knockaert, M., et al, Trends Pharmacol. Sci. 23, 417-425, (2002).
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