CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0119-0010-10mg | $120 | ||
| VD-CCR-0119-0050-50mg | $450 |
SCH 529074 (CAS 922150-11-6)
$120.00 – $450.00
Product Specification
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Appearance:
Cream solid.
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CAS Number:
922150-11-6
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Cat.number:
VD-CCR-0119
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Formula:
C31H36Cl2N6
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MW:
563.56
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Purity:
>=98%.
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Solubility:
100 mM in Ethanol and to 10 mM in DMSO.
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Storage:
-20°C.Protect from light.
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Synonyms:
Not available.
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Size:
10mg, 50mg
Description
SCH 529074 (CAS 922150-11-6) restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.
1. Demma et al (2010) J.Biol.Chem. 285 10198.
2. Essmann & Schulze-Osthoff (2012) Br.J.Pharmacol. 165 328.
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