CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0039-0010-10mg | $60 | ||
| VD-IS-0039-0050-50mg | $270 |
SU 9516 (CAS 377090-84-1)
$60.00 – $270.00
Product Specification
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Appearance:
Orange solid
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CAS Number:
377090-84-1
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Cat.number:
VD-IS-0039
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Formula:
C13H11N3O2
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MW:
241.25
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Purity:
≥98% (HPLC)
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Solubility:
100 mM in DMSO and to 20 mM in Ethanol
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Storage:
+4°C.
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Synonyms:
(Z)-1,3-Dihydro-3-(1H-imidazol-4-yl methylene)-5-methoxy -2H-indol-2-one
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Size:
10mg, 50mg
Description
SU 9516 (CAS 377090-84-1) is a potent, selective cdk2 inhibitor (IC50 values are 0.022, 0.04, >10, >10, 18 and >100 μM for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and proapoptotic effects in vitro.
1. Lane et al (2001) Cancer Res. 61 6170.
2. Yu et al (2002) Biochem.Pharmacol. 64 1091.
3. Gao et al (2006) Mol.Pharmacol. 70 645.
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