CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0123-0005-5mg | $200 | ||
| VD-CCR-0123-0010-10mg | $300 |
Tenovin-6 (CAS 1011557-82-6)
$200.00 – $300.00
Product Specification
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Appearance:
Solid.
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CAS Number:
1011557-82-6
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Cat.number:
VD-CCR-0123
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Formula:
C25H34N4O2S
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MW:
454.6
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Purity:
>95%
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Solubility:
1 mg/mM in ETOH and 20 mg/mM DMSO.
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Storage:
-20°C
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Synonyms:
Tenovin 6
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Size:
10mg, 5mg
Description
Tenovin-6 (CAS 1011557-82-6) the water soluble analog of Tenovin-1 (VD-CCR-0121) and acts as a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. SIRT1 and SIRT2 are protein-deacetylases that belong to the NAD+-dependent class III histone deacetylases. Although the function of sirtuins in humans is not entirely known, in yeast, they have been shown to regulate epigenetic gene expression. Studies show that tenovin-6 increases p53 levels more than tenovin-1 (VD-CCR-0121) and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SRT3 and Tenovin-3 (VD-CCR-0122) inhibits SIRT2.
1. Brooks, C.L. and Gu, W. 2008. Cancer Cell. 13: 377-378.
2. Lain, S., et al. 2008. Cancer Cell. 13: 454-463.
3. Liu, T., et al. 2009. Cancer Res. 69: 1702-1705.
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