CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-AI-0029-0010-10mg | $80 | ||
| VD-AI-0029-0100-100mg | $650 |
Ubiquitin Isopeptidase Inhibitor II, F6 (CAS 157654-67-6)
$80.00 – $650.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
157654-67-6 (HCl salt)
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Cat.number:
VD-AI-0029
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Formula:
C21H21NO
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MW:
303.40
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Purity:
≥97% by HPLC
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Solubility:
DMSO or MeOH
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Storage:
+2°C to +8°C
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Synonyms:
NSC-632839 hydrochloride; 3,5-bis((4-Methylphenyl)- methylene)-1,1-dioxide
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Size:
100mg, 10mg
Description
Ubiquitin Isopeptidase Inhibitor II, F6 (CAS 157654-67-6) is a cell-permeable cross-conjugated ,-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 M in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.
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