CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-GFC-0118-0010-10mg | $70 | ||
| VD-GFC-0118-0050-50mg | $325 |
TX-1123
$70.00 – $325.00
Product Specification
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Appearance:
Yellow solid
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Cat.number:
VD-GFC-0118
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Formula:
C20H24O3
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MW:
312.4
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from Light. Packaged under inert gas.
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Synonyms:
Chemical name: [2-((3,5-di-tert-Butyl-4-hydroxyphenyl)- methylene)-4-cyclopentene-1,3-dione]
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Size:
10mg, 50mg
Description
A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA (IC50 = 2.2, 3.2, and 9.6 M, respectively), while it inhibits EGFR-K and PKC at much higher concentrations (IC50 = 320 M). Displays potent antitumor activity (EC50 = 3.66 and 39 M in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 . It is therefore a more promising candidate as a therapeutic agent for cancer treatment.
Hori, H., et al. 2003. Cell. Mol. Biol. Lett. 8, 528. Hori, H., et al. 2002. Bioorg. Med. Chem. 10, 3257.
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