CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-ESA-0030-0010-10mg | $100 | ||
| VD-ESA-0030-0050-50mg | $400 |
YC-1 (CAS 170632-47-0)
$100.00 – $400.00
Product Specification
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Appearance:
White Solid
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CAS Number:
170632-47-0
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Cat.number:
VD-ESA-0030
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Formula:
C19H16N2O2
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MW:
304.34
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Purity:
>99%
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Solubility:
100 mM in DMSO and to 50 mM in ethanol
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Storage:
RT
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Synonyms:
YC1, YC 1
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Size:
10mg, 50mg
Description
YC-1 (CAS 170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.
1. Ko et al (1994) Blood. 84 4226.
2. Martin et al (2001) Proc.Natl.Sci.U.S.A. 98 12938.
3. Wang et al (2005) J.Pharmacol.Exp.Ther. 312 917.
4. Teixeira et al (2006) J.Pharmacol.Exp.Ther. 317 258.
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