CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-ESA-0031-0010-10mg | $70 | ||
| VD-ESA-0031-0050-50mg | $300 |
ZLN 024 hydrochloride
$70.00 – $300.00
Product Specification
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Appearance:
White Solid
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CAS Number:
N/A
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Cat.number:
VD-ESA-0031
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Formula:
C13H13BrN2OS.HCl
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MW:
361.69
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Purity:
>99%
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Solubility:
100 mM in DMSO
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Storage:
+4˚C
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Synonyms:
ZLN 024 hydrochloride
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Size:
10mg, 50mg
Description
ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.
1. Li et al (2013) Toxicol.Appl.Pharmacol. 273 325.
2. Zhang et al (2013) PLoS One 8 e72092. PMID: 23977216.
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