CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0075-0010-10mg | $50 | ||
| VD-IS-0075-0050-50mg | $200 |
GW 5074 (CAS 220904-83-6)
$50.00 – $200.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
220904-83-6
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Cat.number:
VD-IS-0075
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Formula:
C15H8Br2INO2
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MW:
520.94
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Purity:
>=98%
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Solubility:
100 mM in DMSO
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Storage:
-20°C.Protect from light.
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Synonyms:
3-(3,5-Dibromo-4-hydroxy-benzylidene)- 5-iodo-1,3-dihydr o-indol-2-one
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Size:
10mg, 50mg
Description
GW 5074 (CAS 220904-83-6) is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
1.Lackey et al (2000) Bioorg.Med.Chem.Lett. 10 223.
2.Varga et al (2002) Eur.J.Pharmacol. 451 101.
3.Breslin et al (2003) Am.J.Physiol.Heart Circ.Physiol. 284 H92.
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